Successful Complete Ablation Rate Post a Second Ablation Dose of 30 mCi Radioactive Iodine (I131) in Patients with Papillary Thyroid Cancer

Document Type : Original Paper, Oncology

Author

Nuclear Medicine departments, King Abdulla Medical City (KAMC), Saudi Arabia,

Abstract

ABSTRACT: Ablation outcome in patients with papillary thyroid cancer after a single dose of I131 depends on several factors. No single group has achieved a successful complete ablation rate of 100% and a second ablation dose is needed for patients with residual functioning thyroid tissue. The aim of the current study is to assess successful complete ablation rate post second ablation dose of 30 mCi I131.
Patients and methods: 100 patients with papillary thyroid cancer (T1or T2-N0&M0) candidates for post total thyroidectomy ablation received first ablation dose of 100 mCi. Six months later follow up I131 whole body scan (I131 WBS) was performed. Patients with residual functioning thyroid tissue in the neck received another ablation dose of 30 mCi I131 on out patient basis in the same day of scanning. Follow up I131WBS was performed 6 months later to assess ablation outcome whether complete or incomplete. Results: 91% of patients are females with an overall age range of 17-68 years (mean43±23 years). Successful complete ablation after first 100 mCi I131 ablation dose is 64%, as compared to 72% post second ablation dose of 30 mCi I131.No significant difference as regards age, gender and histopathological details between patients who achieved complete ablation and those with non complete ablation after reablation dose of 30 mCi can be detected .The overall successful complete ablation rate after overall dose of 130 mCi is 90%.
Conclusion: The successful complete ablation rate after a second ablation dose of is higher than first ablation dose of 100 mCi 1131. No significant difference between completely and non-completely ablated patients after the second ablation dose (30 mCi) as regards age, gender and histopathological details. The overall complete ablation rate after 130 mCi is 90%, this figure is significantly higher than the same figure post either first or second ablation dose separately.

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