Objective: The aim of this study was to evaluate the potential significance of 18FFDG PET/CT in detection of local or distant disease recurrence during routine follow up of patients with colorectal cancer (CRC) in comparison with conventional CT. Methods: Sixty seven patients (43 males and 24 females; age range 32-72 years, mean 55.7±9.2 years) with histologically proven CRC previously treated by surgery and chemotherapy. 18FFDG PET/CT and conventional CT were performed for all patients. Diagnostic ability was determined on a patient and on a lesion site basis (loco-regional recurrence, hepatic or extra-hepatic metastases that include LNs, bone and other sites). The final diagnosis was obtained from the results of histopathological examination after surgery or biopsy, or follow-up after at least 6-12 months on the basis of clinico-radiologic or follow up PET/CT. Results: On patientbasis analysis, PET/CT showed higher sensitivity, specificity and accuracy than CT in detection of local recurrence and metastatic lesions (94.6%, 100%, and 95.5% for PET/CT versus 83.9 %, 100% and 86.6% for diagnostic CT, respectively). On lesion-basis analysis, loco-regional recurrence was present in 23 patients, PET/CT detected all 25 lesions (100%) compared to 14/25 lesions (56%) detected by CT. Twenty-six Liver metastatic lesions were detected in 12 patients, PET/CT and CT accurately detected 22/26 (84.6%) and 21/26 (80.7%) hepatic lesions, respectively. PET/CT identified 32/42 LNs (76%) versus 23/42 LNs (55%) identified by CT in 19 patients. PET/CT had higher detectability of bone deposits than CT. PET/CT definitely changed the treatment modality in 28/67 patients (41.8%). PET/CT showed recurrent disease in 5/18 patients with elevated carcino-embryonic antigen who had negative CT. Conclusion: 18F-FDG PET/CT provides high accuracy for detection of recurrent and distant metastases than conventional CT in CRC patients during regular follow up. PET/CT changed the management strategy in a significant number of patients on lesion-based analysis. The use of 18F-FDG PET/CT in the regular follow up of CRC patients is worth considering.
younis, J. (2013). Patient And Lesion-Based Analysis Of 18F-FDG PET/CT Compared With Conventional CT During Follow Up of Patients With Colorectal Carcinoma. Egyptian Journal Nuclear Medicine, 8(8), 45-54. doi: 10.21608/egyjnm.2013.5459
MLA
jehan ahmed younis. "Patient And Lesion-Based Analysis Of 18F-FDG PET/CT Compared With Conventional CT During Follow Up of Patients With Colorectal Carcinoma". Egyptian Journal Nuclear Medicine, 8, 8, 2013, 45-54. doi: 10.21608/egyjnm.2013.5459
HARVARD
younis, J. (2013). 'Patient And Lesion-Based Analysis Of 18F-FDG PET/CT Compared With Conventional CT During Follow Up of Patients With Colorectal Carcinoma', Egyptian Journal Nuclear Medicine, 8(8), pp. 45-54. doi: 10.21608/egyjnm.2013.5459
VANCOUVER
younis, J. Patient And Lesion-Based Analysis Of 18F-FDG PET/CT Compared With Conventional CT During Follow Up of Patients With Colorectal Carcinoma. Egyptian Journal Nuclear Medicine, 2013; 8(8): 45-54. doi: 10.21608/egyjnm.2013.5459
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