Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.

Document Type : Original Paper, PET/CT

Authors

1 Nuclear medicine unit, National cancer institute, Cairo University

2 radiodiagnosis department, kasr El-ainy hospital, Cairo University

3 Nuclear Medicine Unit, National Cancer Institute (NCI) Cairo University, Cairo, Egypt.

4 clinical oncology and nuclear medicine department

Abstract

Aim: to evaluate the value of F-18 FDG PET/CT compared to conventional imaging in change the management of patients with differentiated thyroid cancer before radioactive iodine ablation. Material &Methods: This retrospective study was conducted on hundred twenty-four patients (92 females and 32 males), with pathologically proven DTC. Baseline whole body F-18 FDG PET/CT was done before RAI-131 therapy, then correlated with neck U/S and CT chest findings. Results: The study group was including 92 female and 32 male patients. The F-18 FDG PET/CT was positive in 65 sites in 38 patients (thyroid bed in 22, 15 in cervical LN) and distant sites in 28 patients. Neck U/S and F-18 FDG PET/CT loco-regional assessment showed fair agreement with a statistical significance (P value of <0.001) in detecting regional nodal lesions but no significance difference in operative bed lesions. The degree of agreement of F-18 FDG PET/CT with CT chest results was also conducted using the Kappa test and it showed fair to moderate degree of agreement, F-18 FDG PET/CT results changed the management of 29 patients accounting for 23.4% of the patients.
Conclusion: The initial F-18FDG PET/CT before RAI-131 ablation may change the management in some patients as compared to other imaging modalities in differentiated thyroid cancer and in planning for proper dose of radioiodine therapy.

Keywords

Egyptian Journal Nuclear Medicine
Volume 25, Issue 2
December 2022
Pages 63-77

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