Does Metabolic liver steatosis has impact on Deauville criteria in Lymphoma patients in 18F-PET/CT.

Document Type : Review Article

Authors

1 Nuclear medicine department ,faculty of medicine, Cairo university.

2 department of Oncology and Nuclear medicine, faculty of medicine, Cairo university, Cairo, Egypt

Abstract

Lymphoma, broadly divided into Hodgkin's and non-Hodgkin's lymphoma, and it accounts for one of the most common malignant diseases in the general population .They are heterogeneous group of lymphoid malignancies. PET-CT with 18F-FDG is a standard staging procedure for most lymphoma subtypes. Liver uptake of 18F-FDG is taken as the reference tissue in interpretation of Deauville score (DS), which is considered a response assessment.18F-FDG PET/CT has a role in evaluating prevalence of hepatic steatosis in patients with lymphoma and the effect of hepatic metabolic activity due to steatosis using SUVmax , SULmax on Deauville score . Steatosis was diagnosed on the unenhanced CT part of PET/CT examinations using a cutoff value of 42 Hounsfield units. Both maximum standardized uptake value (SUVmax) and SULmax were recorded on the liver and the tumor target lesion. DS was then computed. There was no significant difference in hepatic steatosis during their time course of their treatment in 18F-PET/CT. Liver SUVmax was increasing with high body mass index (BMI) in follow-up PET/CT studies . Regarding SULmax, there was no correlation with BMI. There was no change in interpretation of DS using either SUVmax or SULmax. Steatosis has no practical issue regarding liver metabolic activity (either SUVmax or SULmax) in interpretation of DS. Liver SUVmax is affected by body weight. Unlike, SULmax is not affected by body weight.

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